TLRs of Our Fathers

Lessons of our fathers.

First, let me begin by apologizing to Beth McNally, our vice president, to my mother and to my wife, and to all the other women who may be offended by the title of my talk today. I mean no insult or discrimination. Rather, I chose this title because I would like to dedicate my comments to the memory of my own father, Franklin Epstein (Figure 1), who was a long-standing member of these associati...

[The land of our fathers].

TLRs and chronic inflammation.

After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the homeostasis of commensal flora and in the r...

TLRs as miRNA receptors.

MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can be found circulating within exosomes secreted by cancer cells. In addition to being promising cancer biomarkers with diagnostic, prognostic, and theranostic implications, circulating miRNAs have also important biologic functions: they can...

Targeting of TLRs Inhibits CD4